Secure multi-region VPC architecture spanning us-east-1 and us-west-2 with Route 53 DNS failover, WAF protection, and cross-AZ redundancy. Traffic flows from users through Route 53 to an Internet Gateway and ALB, which distributes requests across EC2 t3.medium instances in private subnets across two availability zones. RDS Primary in us-east-1 replicates synchronously to RDS Standby in the same region, then asynchronously to an RDS DR Replica in us-west-2 for disaster recovery. This architecture demonstrates defense-in-depth with security groups isolating database tiers, NAT Gateways enabling outbound connectivity, and public/private subnet segmentation. Solutions architects can fork this diagram to customize CIDR ranges, instance types, or add additional regions for global resilience. The design balances cost optimization with RPO/RTO requirements typical of production workloads.