Multi-region AWS e-commerce architecture spans North America (us-east-1), Europe (eu-west-1), and Asia (ap-southeast-1) with global traffic distribution via Route 53, CloudFront CDN, and Global Accelerator. Each region deploys a complete microservices stack: API Gateway behind WAF, Application Load Balancers routing to Product Catalog, Order Service, Inventory Service, Payment Service, and User Service, backed by ElastiCache Redis for session caching and Aurora PostgreSQL with cross-region read replicas. DynamoDB Global Tables replicate order data across all regions while SQS queues and SNS topics coordinate asynchronous order processing and inventory events within each region, with KMS encrypting payment data and OpenSearch indexing product catalogs for low-latency search. This architecture delivers sub-100ms response times to global customers through regional failover, active-active replication, and edge caching, demonstrating AWS best practices for high-availability e-commerce at scale. Fork this diagram on Diagrams.so to customize region placement, add Cognito user pools, integrate Step Functions for order orchestration, or export as .drawio for architecture reviews.