Multi-zone Azure architecture for home medical device monitoring integrates IoT Hub, AKS microservices, and real-time analytics across two availability zones with full redundancy. Patient mobile apps and clinician web portals connect through Azure Front Door, WAF, and API Management, while home medical devices stream telemetry via IoT Hub to Event Hubs and Stream Analytics for live processing. Azure SQL, Cosmos DB, and PostgreSQL replicate across zones; Azure ML and Cognitive Services enable predictive alerts and NLP-driven care workflows through Logic Apps and Function Apps. This enterprise-grade design ensures HIPAA compliance, high availability, and disaster recovery for critical patient monitoring at scale.