Multi-region Azure web application architecture combines Azure Front Door for global load balancing with Application Gateway for regional traffic management and WAF protection. Traffic flows from users through Azure Front Door to Application Gateway in a Virtual Network (10.0.0.0/16), which routes requests to App Service in a private subnet while enforcing WAF Policy rules. App Service connects to Azure SQL Database and Azure Cache for Redis via Private Link endpoints, ensuring data plane traffic never traverses the public internet. Azure Monitor and Log Analytics provide centralized observability across all components, with NSGs securing both public and private subnets. This architecture demonstrates Azure best practices for global availability, defense-in-depth security, and private connectivity for PaaS services. Fork this diagram on Diagrams.so to customize subnet ranges, add additional regions, or integrate Azure Key Vault for secrets management.